Senior Computational Genetics Scientist - Berkshire

Paramount Recruitment Ltd


Job ID :

14443


Company Type :

Staffing Firms


Industry :

Pharmaceuticals


Education Level :

Bsc


Address 1 :

United Kingdom,Berkshire,Berkshire,


Key Skills :

Genetics, Pharmacogenetics, Statistical Genetics, Statistical Geneticist, Phenome Wide Association S


Salary :

Negotiable


Date Posted :

07 Mar, 2019



Company Name :

Paramount Recruitment Ltd


Location1 :

Berkshire




Job Category :

Pharma Research & Development Jobs


Experience :

Fresher


Job Type:

Permanent


Travel Amount:

negotiable





Description

Senior Computational Genetics Scientist - Berkshire

Statistical Geneticist - Phenome Wide Association Studies - Pharmaceutical - Drug Discovery

*Contract duration: 12 months
*Full time 37.5 hours
*Office: Berkshire
*Excellent pay rate
*Starting ASAP


An exciting new position has become available with a well-known pharmaceutical company in the UK for a Senior Computational Genetics Scientist / Statistical Geneticist. This human genetics group works closely with the internal therapeutic areas to use human genetics to identify and validate drug targets. Phenome Wide Association Studies (PheWAS) is a powerful tool for indication discovery, drug repurposing and for the prediction of safety signals for drug discovery and development programs. One of the current aims of the group is to create a PheWAS resource tailored to the needs of the company therapeutic area teams.

This role will be primarily responsible for the implementation of a PheWAS solution that can provide translational insight to de-risk therapeutic projects. Responsibilities will include integration of summary statistics from public PheWAS resources, execution of GWAS in specific disease areas, co-development of a query and visualization interface and development of innovative analytical approaches to support maximum derivation of value from the resource.

The successful candidate will be a key member of a highly motivated and dynamic multidisciplinary project team consisting of geneticists, computational biologists and IT experts.

Responsibilities:

*To develop and implement a Phenome Wide Association (PheWAS) resource
*To internalise and integrate prioritised external data resources
*To develop, script and implement key functionality and analytical approaches e.g. SNP-to-gene mapping, visualization of PheWAS results
*To develop internal processes and pipelines to run GWAS studies in support of PheWAS analysis in a cloud computing environment
*To develop and implement innovative analytical approaches to add additional value e.g. pathway-level burden tests, improved case ascertainment
*Secondary
*To work with project teams to define and run GWAS and PheWAS analyses and support interpretation and follow up
*To be responsible for monitoring developments in the external landscape (including but not limited to emerging data sources, analytical approaches, consortia, representative bodies etc.) and supporting decision making for which to pursue


Experience Required:

*MSc or higher in related field
*5 years plus experience of devising, implementing and running genetic projects, with direct experience of GWAS and PheWAS, preferably within a Pharma environment
*Direct experience of generating, analysing and using genetic data generated through multiple platforms, including next generation sequencing (NGS) and associated analytical approaches.
*Direct experience of implementing and running PheWAS and GWAS analyses
*Good knowledge of statistics, with specific experience in, and application of statistical genetics.
*Advanced computational skills: proficiency in using R, python, bash and experience of working in a cloud environment
*Ability to conceive, develop and implement novel approaches
*Problem solving skills

Preferred:
*Expertise in methods for functional interpretation of genomics data such as pathway enrichment, functional module detection, causal reasoning
*Experience/understanding of ML/AI approaches
*Experience of the application of genetics and genetic approaches to drug discovery and development
*Knowledge of CWL (common workflow language)

If you are interested in discussing this further please contact Jade on +44 121 616 3472 or drop your CV across to jpage@pararecruit.com

Keywords: Genetics, Pharmacogenetics, Statistical Genetics, Statistical Geneticist, Phenome Wide Association Studies, GWAS, Pharmaceutical, Drug Discovery, Bioinformatics, NGS, Python, Data Analysis

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities.


Company Name:

Paramount Recruitment Ltd


Headquarters:

No. 5 Lower Temple Street,No. 5 Lower Temple Street


Sector:

Staffing Firms


Country:

United Kingdom


Zipcode:

B1 1QU


Website:

www.paramountrecruitment.co.uk


Employees:

less than 100


Industry:

Pharmaceutical Recruitment


City:

Birmingham


Phone No. :

+44 (0)121 616 3460


Specialist in Permanent, Contract and Interim recruitment solutions to the Pharmaceutical and Life Science industries throughout Europe.

Our goal is to assist our candidates in finding that “perfect fit” between individual skills and experience and the right career opportunity. We identify and only present the positions that accurately reflect a chosen professional path. We discuss opportunities in detail, respect choices and ask permission prior to presenting any details to prospective clients. We brief and prepare every candidate for client meetings, and once the interview process is complete, provide feedback in a timely manner.

Our clients choose Paramount because:
• We are a Corporate Member of REC (Recently Inspected)
• We aspire to build long-term partnerships
• Our consultants are highly trained with expert market knowledge
• We are one of the most effective advertisers on the Internet
• We provide tailored Recruitment Solutions
• We keep up-to-date with Industry information – Salary scales, market knowledge, skills shortages

For more information,visit www.paramountrecruitment.co.uk.

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Established in January 2003, Paramount Recruitment is an independent recruitment consultancy which has grown to be one of the leading recruiters to the Healthcare, Pharmaceutical and Scientific industries, throughout the UK and Europe.

Our Vision is to be internationally recognised and admired as the number one recruitment solutions provider to the Healthcare Pharmaceutical and Scientific industries.

Our Mission is to employ the best Consultants, whose aim is to deliver a professional and superior service to ensure our clients achieve their business goals and our candidates attain their career aspirations.
 
Our Values define who we are as an organisation and what makes us different. They influence the way we work with each other – and the way we serve our clients and candidates:

  • Respect - Paramount people listen, engage and contribute to ensure we make  the best possible decisions.  We are proud to work in recruitment.  Our diversity    makes our team uniquely adaptable to whatever challenges be it location, industry or culture we work in.
  • Integrity - Credibility means everything.  We are honest and transparent in our approach with everyone.
  • Entrepreneurial - We make it our business to excel when others can’t.  We relish the opportunity of a challenge using innovative and unique solutions.  We strive to be the agency of choice.
  • Experts Continuous knowledge building and sharing is central to our success.  We work in partnership with clients and candidates, our combined knowledge of industry and recruitment ensures we match the right person to the right job at the right time.
  • Success – At Paramount we recognise and reward achievement, we nurture an environment where people can fulfil and maximise their potential.

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