DSP Scientist - Antibodies- Reading

Paramount Recruitment Ltd

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Job ID :


Company Type :

Staffing Firms

Industry :

Science and Research

Education Level :

Bsc,Master of Science,phD

Address 1 :

United Kingdom,--Reading,Reading,

Key Skills :


Salary :


Date Posted :

18 Feb, 2019

Company Name :

Paramount Recruitment Ltd

Location1 :


Job Category :

Biotech Jobs

Experience :


Job Type:


Travel Amount:



Downstream Processing Scientist- Antibodies- Reading

A unique and exciting opportunity has arisen for a Downstream Processing Scientist- Antibodies to join an international biopharmaceutical company who have recently opened a brand new state-of-the-art manufacturing process development facility in Reading. As an organisation they are entering into a significant period of growth and investment to support the next phase of development for their innovative R&D pipeline.

The main responsibilities of the role are to perform downstream process development, optimisation and characterisation studies for antibody based production processes. The role is predominantly lab based and as the laboratory is newly established, there will be some involvement in supporting the setup of lab systems and procedures, equipment commissioning, preparing documentation and cross training in upstream and analytical procedures to support the broader team.

Key Duties:

*Support the technology transfer of downstream processes for bio-therapeutic products
and later externally to 3rd party contract manufacturer(s).
*Perform process development studies to increase process understanding, establish proven acceptable ranges, optimise performance and characterise/validate downstream unit operations.
*Purification techniques include;
Protein A affinity, ion exchange, hydrophobic interaction, mixed mode, hydroxyapatite chromatography, in column (and membrane) format.
Bench scale tangential, depth, sterile and virus (sizing) filtration studies.
*Perform in-process analytical tests as part of a larger team.
*Perform data analysis and interpretation, delivering internal, external presentations and
preparing reports suitable for GLP/GMP use and CMC submissions.
*Prepare other GLP/GMP documentation to support above activities, including SOPs, URSs, raw material/in-process specifications.
*General housekeeping, stock taking, ordering, laboratory cleaning, reagent/buffer prep.


*Bsc/MSc in Biological or Bio-Engineering discipline with 2 years+ of industry related
experience, preferably in therapeutic antibody process development
*Experience developing downstream processes suitable for GMP
*Experience executing downstream characterisation studies within BLA programs strongly
*Knowledge and experience of chromatography using AKTA systems (Pure/AVANT) and UNICORN software is essential.
*Experience performing and sizing sterile, depth, tangential and virus filtration steps.
*Understanding of protein characteristics and their influence on protein separation.
*Experience undertaking technology transfer into/out of companies preferred.

This is a fantastic opportunity to be involved in the set-up of a brand new facility and to really have an impact on the science of the company. In return the company are offering a very competitive salary and benefits package. For further information on this superb opportunity please feel free to contact myself, Lauren Gripton of Paramount Recruitment, lgripton@pararecruit.com

Keywords- DSP, process development, downstream down-stream, processing, antibodies, antibody, protein, purification.

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities.

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